Faculty & Research

Jeffrey L. Neul, M.D., Ph.D.

Cynthia and Anthony G. Petrello Endowed Scholar, Jan and Dan Duncan Neurological Research Institute

Assistant Medical Director, Blue Bird Circle Rett Center, Texas Children's Hospital

Associate Professor, Departments of Pediatrics (Section of Neurology), Molecular and Human Genetics, Molecular Physiology and Biophysics; Programs in Developmental Biology, Translational Biology and Molecular Medicine; Baylor College of Medicine

Research focus: Autonomic dysfunction in Rett syndrome; role of MeCP2 in regulating respiratory and cardiac rhythms; MeCP2 function in dopaminergic neurons; studying the natural history of the disease in children

The Neul lab is taking a three-pronged approach to developing a treatment for Rett syndrome. The first task is clinical: developing a detailed understanding of the natural history of Rett syndrome. To provide the necessary framework for evaluating the efficacy of potential therapies during clinical trials in children, Dr. Neul is following Rett patients over time in order to map the disease course and the long-term effects of treatment.

The second line of attack is to test currently available treatments on the mouse model of Rett syndrome. If any drugs that target individual symptoms such as breathing irregularities, motor difficulties, heart abnormalities, or seizures show promise in the animal model, Dr. Neul will use this information to design clinical trials for affected children.

The third approach is to understand the molecular changes that result from the lack of a properly functioning MeCP2 protein in brain cells. By characterizing the molecular changes within the brains of animal models, Neul and his team have been able to identify alterations in specific neurotransmitter systems. The ultimate goal is to find ways to replace, or more likely, circumvent the malfunctioning MECP2 gene. This is a complicated task that will require chemical or pharmacological tools to either correct or bypass the defective gene responsible for disease development. The hope is that addressing the mutated MECP2 gene will not only alleviate the symptoms, but treat the underlying disease.

Publications

Heterozygous De Novo and Inherited Mutations in the Smooth Muscle Actin (ACTG2) Gene Underlie Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome.
Wangler MF, Gonzaga-Jauregui C, Gambin T, Penney S, Moss T, Chopra A, Probst FJ, Xia F, Yang Y, Werlin S, Eglite I, Kornejeva L, Bacino CA, Baldridge D, Neul J, Lehman EL, Larson A, Beuten J, Muzny DM, Jhangiani S, Baylor-Hopkins Center for Mendelian Genomics, Gibbs RA, Lupski JR, Beaudet A

View a complete list of publications by Jeffrey L. Neul, M.D., Ph.D.

Contact Information

Jeffrey L. Neul, M.D., Ph.D.

Email:
jneul@bcm.edu

Phone:
832-824-8808
832-824-8858 (Fax)

Address:
Baylor College of Medicine
Department of Pediatrics
Jan and Dan Duncan Neurological Research Institute
at Texas Children's Hospital
1250 Moursund St., Suite 1250
Houston, TX 77030

To learn more:
Contact: nri_info@texaschildrens.org